Esketamine Therapy is an FDA-approved nasal spray consisting of anesthetic ketamine and is prescribed for adults with treatment-resistant depression (TRD). This means it is intended for individuals who have not responded well to at least two different antidepressants. Patients with depression may use Esketamine alongside their oral antidepressant since it is not a standalone treatment. Esketamine targets the brain’s glutamate system, increasing glutamate levels to promote new neural connections. This method works faster than solely taking an oral treatment. The therapy is administered under a Madisonhealth professional due to potential side effects such as dissociation, dizziness, increased blood pressure, or sedation. Madisonhealth provides this promising option for those who have struggled to find relief through traditional medications.